tag:blogger.com,1999:blog-83183207524649694022024-03-05T05:32:44.002+01:00The All Results JournalsThe main objective of The All Results Journals focuses on recovering and publishing secondary (or negative) results in main fields of science. These experiments should be taken into account as a vital key for the development of science. These ´secondary´ results are the catalyst for a real science-based empirical knowledge.Unknownnoreply@blogger.comBlogger180125tag:blogger.com,1999:blog-8318320752464969402.post-19001731591638579742019-01-22T09:24:00.000+01:002019-01-22T09:25:38.855+01:00Interview with Dr Sylvia OrtegaWe have interviewed last week Dr. Sylvia Ortega Martinez, a passionate Spanish neuroscientist.
She got her international PhD in Neuroscience at Universidad Autónoma de Madrid (July 2013). Her research interest is the role of the new neuron formation in a specific brain area (known as Adult Hippocampal Neurogenesis (AHN)), as a key target in neurodegenerative and neuropsychiatric diseases. IndeedUnknownnoreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-57130744240179473762018-02-26T13:03:00.003+01:002018-02-26T13:03:46.359+01:00Efforts to combat A. Baumannii Infections: Meropenem Added to Colistin study resultsAccording to a researched report in The Lancet Infectious Diseases, the addition of meropenem to colistin provides no additional therapeutic benefit to patients suffering with A. baumannii or other carbarpenem-resistant bacteria.
This question was the focus of a random trial covering three countries on an open-label, controlled basis. While studies conducted prior to the start of this one showed Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-84242411899945537242017-09-14T11:47:00.003+02:002017-09-14T11:47:56.020+02:00Medical Research's Future Boosted by Changes in Clinical TrialsAmid all the upheaval you see on the news, the fact that a revolution in science is going on may slip by unnoticed. The biomedical community has long been expressing concerns over how reliable various published studies are. The complaints involve the failure to repeat the research outcomes when scientists attempt to reproduce them independently. This has led to a new paradigm for scientific Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-31214266875982394842017-08-23T17:59:00.000+02:002017-08-23T18:00:59.477+02:00Violence against women in EUViolence against women can be addressed through a fundamental rights lens. It is a violation of human dignity and, in its worst form, it violates the right to life. It is also an extreme expression of inequality on the ground of sex. Violence against women exists in every society, and encompasses different forms of physical, sexual and psychological abuse. However, despite its scale and social Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-85732761512243723032016-08-31T07:00:00.000+02:002016-08-31T07:00:10.971+02:00A brief overview in Adult Neurogenesis: the most fascinating brain discovery over the last 50 yearsProbably one of the most exciting scientific findings of the last 50 years is the discovery that discrete brain regions generate new neurons throughout life, a concept known as adult neurogenesis. Despite the neurogenesis importance acquired nowadays, this emergent concept remained obscure until neurogenesis was found to occur in the brain of adult humans (Eriksson et al., 1998). In fact, until Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-65930481868525244602016-08-29T08:00:00.000+02:002016-08-29T08:00:27.624+02:00Satellite cells do not mediate zebrafish extraocular muscle: when an initial negative result guides you to a more scientifically relevant findingDegenerative and atrophic muscle diseases such as muscular dystrophies, as well as extensive muscle damage or loss related to trauma, tumor resections and other conditions, represent one of the most important public health concerns. It is estimated that the combined cost of the relatively uncommon disorders amyotrophic lateral sclerosis, Duchenne muscular dystrophy, and myotonic muscular Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-66150838385475868592016-06-16T13:28:00.001+02:002016-06-16T13:28:48.992+02:00Could we change the way we design our clinical trials to minimize failures?We all hear from time to time that clinical trials fail sometimes, but the question today is why do they fail? And why should everyone know when something fails? Could we change the way we design our studies to minimize failures if we know why they fail?
Any regulations set for the clinical trials have a common goal to harmonize the procedures for clinical trials while making sure of the Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-82636167440918123972015-10-01T07:00:00.000+02:002015-10-01T07:00:02.477+02:00Negative results on cold fusion experiments
What is Cold Fusion?
The dictionary definition of cold fusion is a nuclear fusion occurring at or close to room temperature. It is only a theory at this point in time. It's never actually been proven. There are some claims from people saying they've achieved it but they have all been debunked. We'll delve into that later, this first section is just to get your feet wet. An introduction to get Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-43585102078359290432015-09-14T15:47:00.001+02:002015-09-14T15:47:24.503+02:00Increasing clinical trials reliability The new clinical trial regulation (EU Regulation No. 536/2014), created in April 2014 is in full evaluation to the end of May 2016. Its goal is to harmonize the procedures for clinical trials across the EU while making sure of the safety of clinical trial volunteers, the ethicality of trials and the dependability and productive effect of data derived. It advocates increasing reliability with Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-38773772225276873742015-09-09T09:43:00.000+02:002015-09-09T09:43:02.938+02:00Winter is coming: an overview on ice-nucleating bacteriaAt temperatures between 0 ° C and -40 °C, below its melting point, water can remain liquid without freezing spontaneously; in this state, water is supercooled. To crystallize, it is necessary the creation of nuclei around which crystal structures can be formed. The origin of these nuclei or catalysts for ice formation is very diverse, ranging from mineral, including airborne dust or sand, to Unknownnoreply@blogger.com1tag:blogger.com,1999:blog-8318320752464969402.post-49045210444115261152015-06-26T06:30:00.000+02:002015-06-26T06:30:01.323+02:00Making social media research more reliable and reproducible
The social media revolution is a good data source for those scientists interested in human behavior.
Juergen Pfeffer and Derek Ruths, in a scientific paper based on the shortcomings of studies about social media, wrote, “Powerful computational resources combined with the availability of massive social media data sets has given rise to a growing body of work that [measures] population Belénhttp://www.blogger.com/profile/15055148758905061904noreply@blogger.com1tag:blogger.com,1999:blog-8318320752464969402.post-20833010709527026782015-06-12T06:30:00.000+02:002015-06-12T06:30:00.071+02:00Negative results of CETUXIMAB
The Journal of Clinical Oncology has removed an editorial about a clinical study that analyses the efficacy of cetuximab (Erbitux, Merck in Europe; Bristol-Myers Squibb/Eli Lily in the United States) in the treatment of a particular type of metastatic colorectal cancer (CRC).
The article was available online since November 17th in the section of the journal called Comments and Controversies, Belénhttp://www.blogger.com/profile/15055148758905061904noreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-58338165728626402015-05-29T06:00:00.000+02:002015-06-07T09:37:43.200+02:00Reproducibility of Research and Preclinical Validation: Problems and Solutions
Many scientific reports and literature present a considerable lack of reproducibility which causes high rates of failure when validating highly promising preclinical observations in clinical research. In these types of studies and especially in cancer research, there is a list of technical reasons that prevent from reproducing the experiments. The combination of all these reasons result in the Belénhttp://www.blogger.com/profile/15055148758905061904noreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-83739605638798022012015-05-15T06:00:00.000+02:002015-05-15T06:00:07.119+02:00Negative Results in Progesterone Research
It is known that medical investigations are very important in finding new treatments and alternatives to different illnesses. Nevertheless, the study of failed studies is also important to avoid time, money and undesirable adverse effects.
Recently, a failed study about progesterone has been discovered.
Leopoldo Montavo, a mason from Austin, had a serious car accident some years ago while he Belénhttp://www.blogger.com/profile/15055148758905061904noreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-59231308495563162322015-04-30T06:00:00.000+02:002015-04-30T06:00:06.416+02:00Is the “Bilingual Advantage” Skewed by Publication Bias?
In the past, research about bilingual speakers as an advantage for cognitive functions and executive control would be subjected to Second Opinion columns (such as this one).
Recently, a group of scientists from the University of Edinburgh and the University of Sassari- who themselves have published research that supports the idea that bilinguals have a cognitive advantage — have revealed Belénhttp://www.blogger.com/profile/15055148758905061904noreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-44928192907988018312015-04-17T06:00:00.000+02:002015-04-17T06:00:01.359+02:00NIH cites European precedent in call for disclosure of clinical trial data
The aim of publishing more clinical trial data has been introduced beyond Europe. In this way, every researcher of the U.S. National Institutes of Health (NIH) will have to publish a complete report of the results of their work, regardless of whether the trial succeeded or failed.
This is focused on correcting publication bias, since negative results are never included, according to the NIH. Belénhttp://www.blogger.com/profile/15055148758905061904noreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-41251461429570689252015-04-03T06:00:00.000+02:002015-04-03T06:00:05.185+02:00Why women leave academia and why universities should be worried
Young women scientists leave university more than men due to three reasons. As PhD candidates, lots of women realize that (i) the characteristics of academic degrees are unattractive, (ii) the impediments they will meet are unbalanced, and (iii) the sacrifices they will have to make are great.
This is the conclusion of The chemistry PhD: the impact on women's retention, a report for the UK Belénhttp://www.blogger.com/profile/15055148758905061904noreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-41273909069569092842015-03-27T06:00:00.000+01:002015-03-27T06:00:06.606+01:004 sources of errors for monitoring glucose levels
Diabetes is a very common pathology nowadays. Diabetic patients must control their blood glucose levels at least once a day, and this is where the problem starts.
Blood glucose monitoring often includes important errors that affect patients and providers. This inaccuracy is due to strip, physical, patient, and pharmacological factors.
1. STRIP FACTORS
There is usually a strip-to-strip Belénhttp://www.blogger.com/profile/15055148758905061904noreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-69252303290687563992015-03-13T06:00:00.000+01:002015-03-13T06:00:04.556+01:00One step more to combat publication biasThe European Federation of Pharmaceutical Industries and Associations (EFPIA) and The Pharmaceutical Research and Manufacturers of America (PhRMA) have recently bolstered their pledge to improve public health by embracing “Principles for Responsible Clinical Trial Data Sharing: Our Commitment to Patients and Researchers,” whose objective is for additional information to be accessible to all Belénhttp://www.blogger.com/profile/15055148758905061904noreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-89563002775608515522015-02-27T06:00:00.000+01:002015-02-27T06:00:04.047+01:00Why null results rarely see the light of day
The fact that experiments don’t always come to an end due to journals’ requirements is actually an important object of study. This problem, called ‘the file drawer effect’, is being carefully analyzed in order to provide a real insight into the issue.
A recent study started by a group of scientists from the Stanford University reveals that the majority of researchers reject the negative resultsBelénhttp://www.blogger.com/profile/15055148758905061904noreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-52371235261388206122015-02-13T06:00:00.000+01:002015-02-13T06:00:02.839+01:00Open study hopes to put STAP in the past
The STAP stem cells case has been extensively studied this year. A group of Japanese researchers published in Nature their investigation on the synthesis of newly-induced pluripotent stem cells (iPS cells) by bathing somatic cells in acid. However, some researches didn’t agree with their work and decided to reproduce the experience. In this way, Kenneth Lee, one of those scientists opposed to Belénhttp://www.blogger.com/profile/15055148758905061904noreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-81569655441077559062015-01-30T06:00:00.000+01:002015-01-30T06:00:01.773+01:00A history of failure, serendipity and how the lack of funding can end it all
A recent article reflects how a failed experiment conducted in 1979 created a breakthrough in infant care research.
Sam Stein describes how a group of scientists at a research lab of pharmacology headed by Dr. Saul Schanberg were running tests on newborn rats to measure growth-related markers, when a failed experiment led them to rethink how to conduct the study.
Unknowingly, the results Belénhttp://www.blogger.com/profile/15055148758905061904noreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-46389861496098157492015-01-16T06:00:00.000+01:002015-01-16T06:00:05.525+01:00P-curve: A Way of Fighting Publication Bias?
I think we all agree that scientific journals usually do not publish
results unless they are statistically significant. That is enough important to
consider publication bias in order to estimate the true magnitude of a
particular effect.
A variety of techniques have
been developed for this goal. Some authors review publication bias correction
tools that assume selective reporting based onBelénhttp://www.blogger.com/profile/15055148758905061904noreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-91311424539066271572015-01-02T06:00:00.000+01:002015-01-02T06:00:01.578+01:00Ebola caught us by surprise, or may be not…?
The current outbreak in West Africa (first cases documented in March 2014) is the largest and most complex Ebola outbreak since the Ebola virus was first discovered in 1976. On August 28, 2014, the World Health Organization (WHO) warned the public that the number of people affected by Ebola virus could rise to 20,000 within the coming 9 months.[1]
The disease usually has an abrupt onset Belénhttp://www.blogger.com/profile/15055148758905061904noreply@blogger.com0tag:blogger.com,1999:blog-8318320752464969402.post-32706627130255555372014-12-24T18:53:00.000+01:002014-12-24T18:53:00.037+01:00Where negative is not a failure, part IIAlmost 3 years ago, one of our most viral blog posts compiled what we considered the best quotes on mistakes, errors and negative results from famous people and philosophers. We have updated this list with new quotes for you to end our publication year in 2014.
Merry Christmas!
Famous quotes:
"If your experiment needs statistics, you ought to have done a better experiment" --- Unknownnoreply@blogger.com0